- Molecular Formula: C₁₅₂H₂₅₂N₄₄O₄₂
- Molecular Weight: 3367.954 g/mol
- Sequence: H-Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-Lys(Mal)-NH2
- Molecular Formula: C₄₆H₅₆N₁₂O₆
- Molecular Weight: 873.032 g/mol
- Sequence: His-D-Trp-Ala-Trp-D-Phe-Lys
- Enzymatic Resistance & Somatotroph Proliferation: CJC-1295 is an engineered analog representing the functional 29-amino acid chain of endogenous GHRH. It incorporates specific substitutions at the 2nd, 8th, 15th, and 27th positions to dramatically enhance resistance against dipeptidyl peptidase-4 (DPP-4) enzymatic degradation. Preclinical data indicates that CJC-1295 upregulates total pituitary RNA and GH mRNA, indicating localized somatotroph cell proliferation.
- Receptor Mimicry & Systemic Biomarkers: GHRP-6, an opioid analog of Met-enkephalin designed without traditional opioid activity, targets GHS-R1a. Combined exposures demonstrate that GHRP-6 sustains baseline hormone levels, while CJC-1295 drives high-amplitude spikes, elevating mean GH concentrations by 2- to 10-fold under study conditions. This sustained action leads to a documented 46% increase in mean GH levels and a 45% increase in anabolic mediators such as Insulin-Like Growth Factor 1 (IGF-1).
- Nervous Tissue Protection & Cell Survival: Investigative models show that a one-week introduction of GHRP-6 promotes a significant increase in IGF-1 mRNA expression within the hypothalamus, cerebellum, and hippocampus. This local upregulation triggers intracellular phosphatidylinositol kinase survival pathways. Studies highlight a clear shift toward cell survival over apoptosis, driven by the stimulation/phosphorylation of Akt and Bad alongside an increase in anti-apoptotic Bcl-2 proteins.
- CD36 Receptor Preference & Cytoprotection: Beyond neuroendocrine pathways, GHRP-6 demonstrates a unique affinity for CD36 receptors, which modulate fatty acid absorption, immune responses, and macrophage phagocytosis. Researchers explore this pathway in cardiovascular and ischemia-reperfusion models to evaluate the peptide’s ability to limit myocardial tissue scarring and regulate angiogenesis.
- Verified Purity: ≥ 99% purity guaranteed through mass spectrometry and HPLC profiling.
- USA Vetted: Independently verified to ensure structural identity, correct molecular mass, and zero cross-contaminants.
- Research Use Only: This compound is synthesized exclusively for in vitro laboratory experimentation and preclinical evaluation.




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