AICAR for Sale: The Premier AMPK Activator for Metabolic and Cellular Research

AICAR for Sale

Welcome to Planex Supplies, your trusted source for high-purity research compounds. If you are looking for aicar for sale, you have come to the right place. Our AICAR (5-Aminoimidazole-4-carboxamide-1-β-D-ribofuranoside) is a cell-permeable, allosteric activator of AMP-activated protein kinase (AMPK). This AICAR is a purine nucleoside that functions as a prodrug, requiring cellular uptake and phosphorylation to its active metabolite ZMP (5-aminoimidazole-4-carboxamide ribotide), an AMP mimetic that binds the γ-subunit nucleotide-binding site of AMPK. Our AICAR is available in a 50mg lyophilized format, verified by independent third-party laboratories to ensure maximum purity and potency.

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• • Synonyms: Z-nucleotide, 5-amino-4-imidazolecarboxamide ribotide, 5′-Phosphoribosyl-5-amino-4-imidazolecarboxamide, AICA Riboside
  • Molecular Formula: C₉H₁₅N₄O₈P
  • Molecular Weight: 338.213 g/mol

• • AMPK Activation Kinetics and Metabolic Regulation: AMP-activated protein kinase (AMPK) functions as the master metabolic regulator across skeletal muscle, hepatic, and cerebral tissues. AICAR introduction allows researchers to study the downstream suppression of lipogenesis, cholesterol synthesis, and ketogenesis. By activating this enzyme axis, the compound is heavily utilized to examine metabolic adaptations, shifts in lipid profile biomarkers, and fatty acid oxidation patterns during controlled laboratory evaluations.
  • Allosteric Glycogenolysis and Myocardial Energetics: In isolated working heart models, AICAR exposure rapidly increases the tissue levels of myocardial 5-aminoimidazole-4-carboxamide 1-beta-D-ribofuranotide (ZMP). This intracellular accumulation drives glycogen degradation (glycogenolysis) while leaving baseline glycogen synthesis unaffected. Because tissue homogenate metrics show no direct alteration in glycogen synthase (GS) or glycogen phosphorylase (GP) activity, the literature indicates that ZMP directly allosterically activates GP to fuel intact myocardial structures under metabolic stress.
  • Ischemic Preconditioning and Infarct Reduction: In cardiovascular injury and atherosclerosis research, AICAR serves as a key model for cellular preconditioning. Preclinical rabbit and rodent models indicate that the compound suppresses vascular smooth muscle proliferation and mitigates macrophage proliferation triggered by high low-density lipoprotein (LDL) levels. This dual action dampens localized vascular inflammation, resulting in a documented 25% reduction in the size and frequency of myocardial infarct fields while simultaneously optimizing post-ischemia collateral blood flow.
  • Insulin Sensitivity and Muscle GLUT-4 Translocation: Insulin resistance profiles feature a marked loss of skeletal muscle insulin sensitivity alongside accelerated lipid tissue inflammation. In diabetic animal models, AICAR exposure effectively lowers blood glucose levels independent of weight changes. The nucleotide triggers cell-signaling pathways that closely mimic physical exercise, upregulating the expression and translocation of glucose transporter type 4 (GLUT-4) receptors to the cell membrane to optimize insulin-independent glucose clearance.

• • Verified Purity: ≥ 99% purity guaranteed through mass spectrometry and HPLC profiling.
  • USA Vetted: Independent laboratory testing ensures precise nucleotide configuration, proper molecular weight, and complete freedom from residual solvents or cross-contaminants.
  • Research Use Only: This compound is synthesized exclusively for in vitro laboratory experimentation and preclinical evaluation. Make sure to double-check the physical label to confirm this information.

What Does AICAR Do

The question what does aicar do is central to understanding its research potential. AICAR is a potent activator of AMPK, a heterodimeric protein serine/threonine kinase that regulates the energy status of cells to protect them from metabolic stress. Upon cellular uptake via equilibrative nucleoside transporters, AICAR is phosphorylated by adenosine kinase to its active metabolite ZMP, which mimics AMP and binds the γ-subunit nucleotide-binding site of AMPK. What does aicar do at the cellular level? It stimulates AMPK to the same maximal extent (~10-fold) as its natural ligand AMP, though with lower affinity.

This activation leads to the phosphorylation of various metabolic enzymes, activating catabolic pathways (e.g., ketogenesis, fatty acid oxidation) and blocking anabolic pathways (e.g., protein synthesis, lipogenesis). What does aicar do also extends to inhibiting cell proliferation in certain cancer cell lines and reducing gluconeogenesis in hepatocytes. When you buy aicar from us, you are acquiring a compound that is foundational for studying energy metabolism, metabolic diseases, and cellular stress protection.

AICAR Peptide

While often referred to as a peptide, AICAR is technically a nucleoside analog, not a peptide. The term aicar peptide is used colloquially in research contexts to describe this AMPK activator. Understanding this distinction is important for researchers working with aicar peptide in their studies. Our AICAR is a cell-permeable adenosine analog with a molecular formula of C₉H₁₄N₄O₅ and a molecular weight of 258.23 g/mol. It is soluble in water and DMSO and should be stored at -20°C for optimal stability. When you aicar buy from Planex Supplies, you are getting a high-purity compound suitable for a wide range of research applications, from metabolic studies to neuroprotection research.

AICAR Peptide Benefits

The aicar peptide benefits are extensive and well-documented in scientific literature. When you purchase aicar for sale, you gain access to a compound with demonstrated potential in multiple areas of research.

Metabolic Regulation

AICAR is an activator of AMPK that helps regulate various metabolic pathways, including glycolysis and fatty acid oxidation. In hepatocytes, AICAR has been shown to reduce HMG-CoA reductase activity and fatty acid and sterol synthesis. AICAR also inhibits hepatic gluconeogenesis at the level of fructose-1,6-bisphosphatase, which has therapeutic potential in diabetes research.

Cellular Energy Homeostasis

Through AMPK activation, AICAR promotes catabolic pathways that generate ATP and inhibits anabolic pathways that consume ATP, helping cells adapt to energy stress. This metabolic regulation is essential for studies on cellular stress protection.

Anticancer Research

AICAR has demonstrated significant aicar peptide benefits in cancer research. AICAR inhibited the proliferation of mantle cell lymphoma (MCL) cell lines with IC₅₀ values ranging from 0.14 to 0.98 mM. Daily administration of 400mg/kg AICAR in mice with MCL xenotransplants significantly reduced tumor burden compared to control animals within 7 days of treatment. In fibroblasts, AICAR inhibited growth and depleted pyrimidine nucleotide pools.

Neuroprotection

AICAR has shown neuroprotective effects in research models. In astrocyte-enriched glial cells, AICAR prevented increases in iNOS, COX-2, and MnSOD induced by LPS and amyloid-β, and suppressed the expression of TNF-α, IL-1β, and IL-6 induced by LPS and Aβ42. This suggests potential research applications in neurodegenerative disease models.

Cardiac Research

AICAR has been studied for its ability to stimulate cardiac production of the vasodilator adenosine under ischemic conditions. AICAR reached Phase 3 clinical trials for the prevention of reperfusion injury in coronary artery bypass graft surgery.

Muscle Function

AICAR probes AMPKγ3-dependent glucose uptake, with activity abolished in γ3-KO muscle (unlike MK-8722), and suppresses catecholamine-stimulated lipolysis in human adipocytes (where A-769662 and 991 fail) . It also selectively activates AMPKα2-dependent pathways (α2-KO abolishes effect) .

AICAR Supplement

AICAR supplement is a term sometimes used in research and commercial contexts. However, our AICAR is intended strictly for laboratory research use and is not formulated as a dietary supplement. For research on AICAR supplement applications, the pure compound is the appropriate format. Our AICAR is for research use only, not as a consumer AICAR supplement.

AICAR Benefits and Side Effects

Understanding aicar benefits and side effects is critical for responsible research. The aicar benefits are numerous, including AMPK activation, metabolic regulation, and potential anticancer, neuroprotective, and cardioprotective effects. However, researchers should also be aware of potential aicar side effects.

AICAR Side Effects

In research models, AICAR has been shown to inhibit autophagy in rat hepatocytes with an IC₅₀ of 0.3 mM. It also induces apoptosis in rat β cells in a concentration-dependent manner. At high doses, AICAR may cause adverse effects. In vivo studies have used intraperitoneal administration of 500 mg/kg in mice. Researchers should always consult primary literature for detailed aicar benefits and side effects information specific to their research model.

AICAR Peptide Dosage

Determining appropriate aicar peptide dosage is crucial for reproducible research. The aicar peptide dosage varies based on the research model and application.

In Vitro Dosage

For cell culture studies, aicar peptide dosage of 0.5 mM has been shown to inhibit insulin-stimulated glucose uptake to 62% of control cells and reduce GLUT4 translocation by 2.5-fold in 3T3-L1 adipocytes. In astrocyte-enriched glial cells, aicar peptide dosage of 1 mM prevents increases in inflammatory markers induced by LPS and amyloid-β.

In Vivo Dosage

For in vivo studies, aicar peptide dosage of 500 mg/kg has been administered intraperitoneally to C57BL/6J mice. Daily administration of 400 mg/kg AICAR in mice with MCL xenotransplants significantly reduced tumor burden compared to control animals.

AMPK Activation

AICAR increases AMPK kinase activity in isolated hepatocytes with an EC₅₀ of approximately 500 μM . When establishing an aicar peptide dosage, always consult published literature for your specific research model.

AICAR Dosing Chart

An aicar dosing chart helps researchers calculate appropriate amounts for their models. Below is a general aicar dosing chart for reference:

When using an aicar dosing chart, always verify against published literature for your specific model.

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Frequently Asked Questions (FAQ)

Q1: Where can I find AICAR for sale?
A1: You can find aicar for sale at Planex Supplies. Our AICAR is third-party tested. Visit our shop for aicar for sale with full documentation.

Q2: What does AICAR do?
A2: What does aicar do? It activates AMPK, a key regulator of cellular energy metabolism. AICAR is a prodrug that is phosphorylated to ZMP, which mimics AMP and activates AMPK.

Q3: What are the AICAR peptide benefits?
A3: The aicar peptide benefits include metabolic regulation, AMPK activation, anticancer effects, neuroprotection, and cardioprotective effects.

Q4: What is the AICAR peptide dosage for research?
A4: Aicar peptide dosage in vitro studies uses 0.5-1 mM. In vivo, aicar peptide dosage of 400-500 mg/kg has been used in mice. AICAR increases AMPK kinase activity with an EC₅₀ of ~500 μM.

Q5: Are there AICAR side effects?
A5: AICAR can inhibit autophagy in rat hepatocytes (IC₅₀ = 0.3 mM) and induce apoptosis in rat β cells in a concentration-dependent manner. Researchers should monitor for aicar side effects specific to their model.

Q6: Can I buy AICAR for research in the UK?
A6: Yes, you can order aicar for sale uk from Planex Supplies. Our aicar for sale uk includes proper documentation. We provide aicar for sale uk with discreet shipping.

Q7: What is an AICAR dosing chart?
A7: An aicar dosing chart provides reference dosages for different research models. For in vitro studies, aicar dosing ranges from 0.5-1 mM. In vivo, aicar dosing of 400-500 mg/kg has been used in mice.

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