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- Amino Acid Sequence: H-Glu-Asp-Gly-OH (EDG / AC-7 Matrix)
- Molecular Formula: C₁₁H₁₇N₃O₈
- Molecular Weight: 319.27 g/mol
- Formulation Components: Active cytogenetic peptide complex AC-7, stabilized structural microcrystalline cellulose, potato starch, lactose, raw sugars, and Tween-80.
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- Pulmonary Mucosal Stabilization and Inflammation Controls: The inner lining of the mammalian respiratory tract depends on strict cellular regulation to defend against airborne pathogens and toxic materials. Preclinical animal testing suggests that Chonluten operates as a targeted anti-inflammatory agent within lung and bronchial tissues. By normalizing the secretion and clearance mechanics of mucous membrane cells, the tripeptide provides a precise biochemical framework for investigating structural repair under induced asthmatic and Chronic Obstructive Pulmonary Disease (COPD) phenotypes.
- Direct DNA Binding and Epigenetic Bioregulation: Breakthrough research led by pioneering scientists like Dr. Vladimir Khavinson indicates that short di- and tri-peptides cross cellular membranes to interact directly with chromatin structures. Chonluten is hypothesized to bind to specific double-stranded DNA sequences, inducing conformational adjustments that unlock silent genetic regions. This epigenetic activation regulates vital protein translation loops, allowing investigators to observe how short amino acid chains optimize somatic tissue functions at a fundamental molecular level.
- Oncogene Suppression and Senescence Mitigation Kinetics: As mammalian cells age, transcriptional errors increase, shifting downstream loops toward cellular senescence or spontaneous tumor development. Chonluten is actively evaluated for its capacity to slow cell aging by downregulating core oncogenes—the specific mutated segments that drive abnormal cellular proliferation and spontaneous tumorigenesis. This precise modulation stabilizes the homeostatic balance between healthy cell survival and programmed cell death (apoptosis).
- Macrophage Modulation and Antioxidant Cellular Defense: Beyond lung-specific repair pathways, the EDG complex is heavily utilized to study general cytoprotective behavior during intense oxidative stress. The tripeptide triggers downstream metabolic pathways that boost local antioxidant enzyme activity, neutralizing destructive reactive oxygen species (ROS). This cellular shielding downregulates chronic subclinical inflammation, offering a robust model for evaluating systemic immunomodulation and protein turnover dynamics.
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- Verified Purity: ≥ 99% purity guaranteed through mass spectrometry and HPLC profiling.
- USA Vetted: Independent laboratory confirmation ensures absolute consistency, proper amino acid sequence replication, and complete freedom from manufacturing cross-contaminants or unlisted adulterants.
- Research Use Only: This compound is synthesized exclusively for in vitro laboratory experimentation and preclinical evaluation. Make sure to double-check the physical label to confirm this information.
Chonluten Peptide
Chonluten peptide (also designated T-34 tripeptide) is a linear tripeptide composed of L-glutamic acid, L-aspartic acid, and glycine. This chonluten peptide was initially isolated and characterized from neurotoxic dialysate in 1980 and has since been investigated across multiple research axes including stress protection, gastroprotection, and tissue-specific regulation of inflammation and proliferation. The chonluten peptide is part of the Khavinson Peptides® family, characterized by Prof. Khavinson from 1973 onwards, and was initially isolated from animal tissues. When you buy chonluten peptide from Planex Supplies, you are acquiring a compound with a well-documented research history.
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The chonluten peptide benefits in research are wide-ranging and well-documented. When you buy chonluten peptide, you gain access to a compound with demonstrated potential in multiple areas of research.
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Research has shown that Chonluten inhibits in vitro tumor necrosis factor (TNF) production of monocytes exposed to pro-inflammatory bacterial lipopolysaccharide (LPS). This chonluten peptide benefit is linked to a documented mechanism of TNF tolerance, promoting attenuation of inflammatory action. The peptide also inhibits the expression of pro-inflammatory IL-6 cytokine stimulated by LPS on terminally differentiated THP-1 cells. Additionally, Chonluten reduces cell adhesion to activated endothelial cells, a typical pro-inflammatory mechanism.
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Chonluten has been shown to regulate the expression of genes encoding antioxidant and anti-inflammatory proteins. The chonluten peptide has demonstrated the ability to normalize the expression of genes encoding superoxide dismutase (SOD), TNF-α, and COX-2 to control levels in research models. The reparative effect of Chonluten is based on its ability to regulate the expression of genes encoding proteins of the antioxidant defense system and inflammatory reactions.
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Research indicates that Chonluten may support tissue regeneration, particularly in mucosal or epithelial contexts where the expression of antioxidant and anti-inflammatory genes is crucial. The peptide may stimulate granulation tissue formation, fibroblast proliferation, vascular growth, epithelialization, and collagen deposition in research models of mucosal injury.
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Clinical studies have established the effectiveness of Chonluten in the complex prevention and treatment of patients with impaired lung and bronchial function in acute and chronic respiratory diseases of infectious and non-infectious origin. The course application of Chonluten, in addition to conventional therapy in patients with respiratory insufficiency and lung damage, contributed to improved well-being, reduced frequency of cough and asthma attacks, reduced sputum production, and increased physical performance.
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A2: Chonluten peptide (T-34) is a synthetic tripeptide with the sequence Glutamyl-Aspartyl-Glycine (Glu-Asp-Gly) . This chonluten peptide has a molecular weight of 319.27 g/mol.
Q3: What are the benefits of Chonluten peptide in research?
A3: Chonluten peptide benefits include inhibiting TNF and IL-6 production, regulating gene expression of antioxidant and inflammatory proteins, and supporting tissue repair and regeneration.
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