ARA-290 Peptide for Sale | The Non-Erythropoietic EPO Derivative for Tissue Protection Research

ARA 290 for Sale

Welcome to Planex Supplies, your trusted source for high-purity research peptides. If you are searching for ara 290 for sale, you have come to the right place. Our ARA-290 (also known as Cibinetide) is a synthetic 11-amino acid peptide derived from the helix-B domain of erythropoietin (EPO). This innovative ara 290 peptide has a molecular formula of C₅₁H₈₄N₁₆O₂₁, a molecular weight of approximately 1257.31 g/mol, and is available in a 16mg lyophilized format. When you purchase ara 290 for sale from us, you receive a product verified by independent third-party laboratories to ensure maximum purity and potency.

Researchers who seek ara 290 for sale appreciate our transparent documentation, including batch-specific certificates of analysis. Browse our shop to explore our ARA-290 inventory. For related research compounds, visit our buy peptide online category. Our ARA-290 is intended for laboratory research use only, not for human consumption. When you choose ara 290 for sale from Planex Supplies, you can trust that you are receiving a product manufactured to the highest standards.

• • Alternative Designations: Cibinetide, PH-BSP, Helix-B Surface Peptide
  • Amino Acid Sequence: ZEQLERALNSS
  • Molecular Formula: C₅₁H₅₄N₁₆O₂₁
  • Molecular Weight: 1257.3 g/mol

• • Innate Repair Receptor (IRR) Axis Activation: In response to tissue damage, inflammation, or metabolic hypoxia, mammalian systems upregulate the Innate Repair Receptor (IRR)—a specialized heterocomplex composed of erythropoietin receptor and CD-131 (common beta chain) subunits. ARA-290 binds to the IRR across macrophage, microglia, neural, and endothelial cell lines. This interaction initiates a robust intracellular reparative cascade that works at the transcription level to suppress pro-inflammatory cytokine expression and prevent induced cell apoptosis.
  • Retinal Ischemia and Blood-Retinal Barrier Protection: Preclinical research utilizes ARA-290 to explore interventions for ischemic retinal degeneration and diabetic retinopathy (DR) models. In animal subjects with induced retinopathy, compound exposure has been observed to inhibit vascular leakage, reduce retinal tissue edema, and defend against structural degeneration. By preserving the integrity of the tight junctions that form the blood-retinal barrier (BRB), the peptide offers a clear biochemical framework for investigating macro-vascular stability in high-stress ocular microenvironments.
  • Endothelial Colony-Forming Cell (ECFC) Optimization: Reparative angiogenesis relies on the viability of Endothelial Colony-Forming Cells (ECFCs), which act as structural building blocks to heal broken blood vessels. In vitro cultures exposed to hydrogen peroxide (\(H_{2}O_{2}\)) indicate that ARA-290 triggers active pro-survival cell signaling and preserves cellular viability during intense oxidative stress. This protective mechanism is frequently cross-examined in transplantation research to evaluate structural vascular regeneration.
  • Synergistic Vasoreparative Action and Cytokine Suppression: In oxygen-induced retinopathy (OIR) transplantation models, systemic introduction of ARA-290 has demonstrated anti-inflammatory properties, lowering eye tissue levels of core pro-inflammatory cytokines such as interleukin-1 beta (IL-1\(\beta \)) and tumor necrosis factor-alpha (TNF-\(\alpha \)). When ECFCs are introduced into ischemic models alongside ARA-290, the peptide effectively counteracts the pro-inflammatory microenvironment. This co-activation helps the transplanted endothelial cells integrate into damaged networks, resulting in a measurable decline in avascular surface area.

• • Verified Purity: ≥ 99% purity guaranteed through mass spectrometry and HPLC profiling.
  • USA Vetted: Independent laboratory confirmation ensures absolute consistency, proper amino acid sequencing, and complete freedom from residual chemical cross-contaminants.
  • Research Use Only: This compound is synthesized exclusively for in vitro laboratory experimentation and preclinical evaluation. Make sure to double-check the physical label to confirm this information.

What is ARA-290 Peptide?

ARA-290, also known as Cibinetide, is an 11-amino acid peptide (sequence: Pyr-Glu-Gln-Leu-Glu-Arg-Ala-Leu-Asn-Ser-Ser-OH) that was engineered to mimic the three-dimensional structure of the helix-B domain of erythropoietin (EPO). Unlike its parent molecule EPO, ARA-290 is non-erythropoietic, meaning it does not stimulate red blood cell production and is free of the potentially life-threatening side effects associated with EPO.

This ara 290 peptide exerts its effects through selective activation of the Innate Repair Receptor (IRR), a heterodimeric receptor complex composed of the erythropoietin receptor (EPOR) and the β-common receptor (βcR or CD131). When you purchase ara 290 for sale, you are acquiring a compound with a unique mechanism of action that suppresses inflammation, inhibits apoptosis (cell death), and promotes tissue regeneration without the hematopoietic effects of EPO.

ARA 290 Peptide Benefits

The ara 290 peptide benefits are well-documented in preclinical and clinical research, making it a valuable tool for researchers.

Neuropathic Pain Research

One of the most significant ara 290 peptide benefits is its efficacy in models of neuropathic pain. In a rat spared nerve injury (SNI) model, ARA-290 exerted a dose-response effect by significantly reducing mechanical allodynia up to 20 weeks. Doses of 30 and 60 μg/kg showed significant reduction of mechanical allodynia (P = 0.049 and P = 0.001, respectively). The reduction of cold allodynia was significant up to 20 weeks for doses of 3, 10, 30, and 60 μg/kg. These ara 290 peptide benefits were also observed in clinical trials, where ARA-290 significantly improved neuropathic symptoms in patients with sarcoidosis-associated small fiber neuropathy.

Neuroprotection

ARA-290 has demonstrated significant neuroprotective effects in research models. In a mouse model of cerebral ischemia, ARA-290 (30 μg/kg, twice daily) significantly reduced brain infarction volume compared to the MCAO control group. The peptide also reduced tactile allodynia in a rat model of neuropathic pain induced by spinal nerve injury. ARA-290 has been shown to exert similar neuroprotective effects as erythropoietin in cerebral ischemic mice. These ara 290 peptide benefits are attributed to its selective activation of the Innate Repair Receptor, which triggers anti-inflammatory and anti-apoptotic signaling pathways.

Anti-Inflammatory and Tissue Protection

ARA-290 is a potent anti-inflammatory agent that has been shown to reduce inflammation and tissue injury in multiple preclinical models. It reduces wound area in a rat model of punch biopsy-induced dermal injury and a rat model of decubitus ulcer. ARA-290 also reduces organ dysfunction in mice during hemorrhagic shock and suppresses the development of atherosclerosis in hyperlipidemic rabbits. These ara 290 peptide benefits are mediated through the inhibition of the NF-κB pathway, reducing the production of pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6.

Metabolic Research

ARA-290 has shown promise in metabolic research. In diabetic Goto-Kakizaki (GK) rats, ARA-290 (30 μg/kg, s.c.) prevented progressive worsening of glucose control without affecting body weight. It significantly decreased glucose AUCs in intraperitoneal glucose tolerance tests. In clinical studies, ARA-290 led to improvements in metabolic control.

ARA 290 Peptide Dosage

Understanding ara 290 peptide dosage is crucial for reproducible research. The appropriate ara 290 peptide dosage varies based on the research model and application.

In Vitro Dosage

For cell culture studies, ara 290 peptide dosage varies by application. In endothelial colony-forming cells, ARA-290 enhances proliferation, migration, and resistance to H2O2-induced apoptosis.

In Vivo Dosage

For in vivo studies, ara 290 peptide dosage has been extensively characterized:

Rat Neuropathic Pain Model (SNI) :

• Doses of 3, 10, 30, and 60 μg/kg administered intraperitoneally on days 1, 3, 6, 8, and 10 post-surgery

• 30 μg/kg significantly reduced mechanical allodynia (P = 0.049)

• 60 μg/kg showed significant reduction of mechanical allodynia (P = 0.001)

Mouse Cerebral Ischemia Model :

• 30 μg/kg once daily or twice daily

• 100 μg/kg once daily

Diabetic Rat Model :

• 30 μg/kg body weight, subcutaneous, once daily for 4 weeks

Experimental Autoimmune Encephalomyelitis (EAE) Model :

• Low dosage: 35 μg/kg, intraperitoneal

• Higher dosage: 70 μg/kg, intraperitoneal, significantly delayed onset and decreased neurologic severity

ARA 290 Peptide Side Effects

Understanding ara 290 peptide side effects is critical for responsible research. The ara 290 peptide side effects profile is generally favorable at standard research doses.

Clinical Trial Safety Data

In a randomized, double-blind pilot study of 22 patients with sarcoidosis-associated small fiber neuropathy, no safety concerns were raised by clinical or laboratory assessments. ARA-290 was administered at 2 mg intravenously three times weekly for 4 weeks.

Safety Studies

In healthy volunteers, no adverse events have been associated with the administration of a single dose of 70-2000 μg ARA-290 among 36 individuals. The only exception was one individual (with an undisclosed significant prior history of fainting) who fainted shortly after intravenous dose administration of 700 μg ARA-290 and recovered without medical intervention. Fourteen individuals have participated in a multiple dosing study with no serious adverse effects. Single doses of ARA-290 in patients with renal impairment did not raise a safety signal.

ARA 290 Peptide Where to Inject

The question ARA-290 peptide where to inject is common among researchers. ARA-290 has been administered via various routes in research studies.

Intraperitoneal Injection

In animal studies, ARA-290 is commonly administered via intraperitoneal (i.p.) injection at doses ranging from 3-70 μg/kg.

Subcutaneous Injection

Subcutaneous (s.c.) injection has been used in research at doses of 30 μg/kg. In clinical trials, subcutaneous administration of 4 mg daily has been evaluated.

Intravenous Injection

In clinical research, intravenous (i.v.) administration of 2 mg three times weekly has been studied.

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Frequently Asked Questions (FAQ)

Q1: Where can I find ara 290 for sale?
A1: You can find ara 290 for sale at Planex Supplies. Our ARA-290 is third-party tested. Visit our shop for ara 290 for sale with full documentation.

Q2: What is ARA-290 peptide?
A2: ARA-290 (Cibinetide) is an 11-amino acid peptide derived from the helix-B domain of erythropoietin (EPO). Unlike EPO, ARA-290 is non-erythropoietic and selectively activates the Innate Repair Receptor (IRR). When you buy ara 290, you are acquiring a compound with potent anti-inflammatory, anti-apoptotic, and tissue-protective properties.

Q3: What are the ARA 290 peptide benefits in research?
A3: The ara 290 peptide benefits include significant reduction of neuropathic pain in SNI models, neuroprotection in cerebral ischemia, anti-inflammatory effects through NF-κB inhibition, and improvements in glucose control in diabetic models. These ara 290 peptide benefits make it a valuable tool for neuropathic pain, neuroprotection, and metabolic research.

Q4: What is the ARA 290 peptide dosage for research?
A4: Ara 290 peptide dosage varies by model. In rat SNI models, doses of 3-60 μg/kg are used. In mouse cerebral ischemia, ara 290 peptide dosage of 30 μg/kg (once or twice daily) has been used. In diabetic rat models, ara 290 peptide dosage of 30 μg/kg subcutaneously was used. For clinical research, ara 290 peptide dosage of 2 mg IV three times weekly or 4 mg SC daily has been studied.

Q5: Are there ARA 290 peptide side effects?
A5: Documented ara 290 peptide side effects are minimal. In clinical trials, no safety concerns were raised. In healthy volunteers, no adverse events were associated with single doses of 70-2000 μg. The ara 290 peptide side effects profile is generally favorable at standard research doses.

Q6: What is the ARA-290 peptide where to inject route?
A6: ARA-290 peptide where to inject depends on the model. Routes include intraperitoneal (i.p.), subcutaneous (s.c.), and intravenous (i.v.). For ARA-290 peptide where to inject guidance, consult published literature for your specific model.

Q7: What is the ARA 290 dosage chart?
A7: The ara 290 dosage chart provides guidance for various models: rat SNI (3-60 μg/kg, i.p., days 1,3,6,8,10), mouse cerebral ischemia (30-100 μg/kg, i.p.), diabetic rat (30 μg/kg, s.c., daily). For a complete ara 290 dosage chart, consult primary literature.

Q8: Can I buy ARA-290 for research in the UK?
A8: Yes, you can order ara-290 for sale uk from Planex Supplies. Our ara-290 for sale uk includes proper documentation. We provide ara-290 for sale uk with discreet shipping.

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