Adipotide FTPP: The Targeted Apoptotic Peptide for Adipose Tissue Research

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• • Other Known Titles: Adipotide, FTPP (Fat Target Proapoptotic Peptide)
  • Molecular Formula: C₁₅₂H₂₅₂N₄₄O₄₂
  • Molecular Weight: 2611.41 g/mol
  • Sequence: Cys-Lys-Gly-Gly-Arg-Ala-Lys-Asp-Cys—Gly-Gly–(Lys-Leu-Ala-Lys-Leu-Ala-Lys)₂

• • ANXA2-Prohibitin Vascular Homing Kinetics: Adipotide initiates its targeted sequence via its specialized 9-amino-acid homing domain (CKGGRAKDC), which was isolated using advanced phage display techniques. Immunohistochemical profiles indicate this domain exhibits a precise binding affinity for a unique Annexin A2 (ANXA2) and prohibitin (PHB) receptor complex. This complex system is preferentially co-expressed on the surface of endothelial cells within blood vessels supporting white adipose tissues, providing an ideal model for vascular-targeted nanotherapy.
  • CD36 Fatty Acid Transport Regulation: Preclinical research utilizes Adipotide to study how the biochemical interaction between ANXA2 and prohibitin dictates the efficiency of lipid movement. Studies indicate that the ANXA2-prohibitin matrix forms an intricate structural complex alongside the critical fatty acid transporter CD36. This co-existence on the surface of adipocytes is heavily induced by extracellular fatty acids. Inhibiting or targeting this system provides a clear pathway for examining variations in endothelial-to-adipocyte lipid transport and white adipose cell hypertrophy.
  • Mitochondrial Membrane Disruption & Programmed Apoptosis: Once localized cell internalization occurs via receptor-mediated endocytosis, the secondary cargo domain of the peptide—the amphipathic alpha-helical sequence (KLAKLAK)₂—is released. This proapoptotic sequence directly compromises the structural integrity of the host cell’s mitochondrial membranes. This physical disruption initiates an immediate apoptotic cascade, triggering programmed cell death of the localized endothelium, cutting off nutrient pathways, and causing the downstream resorption of established subcutaneous and visceral fat depots.
  • Metabolic Axis Signaling & Ectopic Fat Models: Investigators evaluate this targeted cell death model to explore systemic metabolic changes under accelerated fat loss parameters. Primate and rodent models are monitored to analyze adaptations in insulin resistance, insulin-like growth factor-1 (IGF-1) axis activity, and type 2 diabetes phenotypes. Furthermore, because of its vascular delivery, the peptide is used to evaluate adaptations in intra-organ ectopic fat reserves, such as fat accumulation dynamics within non-alcoholic fatty liver models.

• • Verified Purity: ≥ 99% purity guaranteed through mass spectrometry and HPLC profiling.
  • USA Vetted: Independent laboratory confirmation ensures absolute consistency, proper amino acid sequencing, and freedom from manufacturing cross-contaminants.
  • Research Use Only: This compound is synthesized exclusively for in vitro laboratory experimentation and preclinical evaluation. Make sure to double-check the physical label to confirm this information.

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The question what is adipotide peptide is central to understanding its research potential. Adipotide, also known as FTPP (Fat-Targeted Proapoptotic Peptide) or Prohibitin-Targeting Peptide 1, is a synthetic peptidomimetic compound designed to selectively target the vasculature of white adipose tissue. The molecular formula is C₁₁₁H₂₀₄N₃₆O₂₈S₂, with a molecular weight of approximately 2555.2 g/mol.

When you Buy Adipotide FTPP, you are acquiring a compound with a unique dual-domain structure: a targeting domain (CKGGRAKDC) that binds to specific receptors on blood vessels supplying white adipose tissue, and a proapoptotic domain (KLAKLAK)₂ that induces programmed cell death in those vessels. This adipotide peptide represents a novel approach to adipose tissue research, distinct from traditional metabolic modulators.

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Adipotide FTPP functions through a targeted mechanism that selectively affects the vasculature of white adipose tissue. The targeting domain binds to the annexin A2 (ANXA2) and prohibitin receptor complex present on the surface of endothelial cells in blood vessels supplying fat depots. This binding is thought to confer specificity, allowing Adipotide to distinguish between blood vessels in adipose tissue and those in other tissues. Once internalized, the proapoptotic domain disrupts mitochondrial membranes, leading to apoptosis of the targeted endothelial cells.

This process results in the ablation of the blood supply to adipocytes, causing their subsequent death and resorption. Research suggests that Adipotide may also interact with the PHB-ANXA2-CD36 network to reduce fatty acid uptake into adipose depots. When you Buy Adipotide FTPP, you are acquiring a compound with a mechanism that targets fat cells indirectly by eliminating their vascular support.

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Understanding adipotide ftpp 10mg dosage is crucial for reproducible research. The adipotide dosage chart is based on studies conducted in primate models. In the most significant non-human primate study, obese rhesus macaques received adipotide ftpp at 0.43 mg/kg subcutaneously daily for 28 days. This adipotide ftpp 10mg dosage regimen resulted in approximately 10.6% body weight loss, with reductions in BMI and abdominal circumference. The adipotide dosage chart from this research suggests that the optimal therapeutic dose in primates is 0.43 mg/kg. When establishing a adipotide ftpp 10mg dosage for your research, consult published literature for your specific model. For assistance with adipotide ftpp 10mg dosage, contact our research support team.

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Adipotide is often described as the peptide that kills fat cells, but its mechanism is more accurately described as inducing apoptosis in the vasculature that supplies fat cells. This peptide that kills fat cells works by cutting off the blood supply to adipose tissue, leading to fat cell death. Research suggests this peptide that kills fat cells may cause rapid and long-lasting weight reduction in primate models. When you Buy Adipotide FTPP, you are acquiring a peptide that kills fat cells through a unique vascular targeting mechanism.

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Q2: What is Adipotide peptide?
A2: Adipotide is a synthetic peptidomimetic compound designed to selectively target the vasculature of white adipose tissue. This adipotide peptide consists of a targeting domain (CKGGRAKDC) and a proapoptotic domain (KLAKLAK)₂.

Q3: What is the Adipotide FTPP dosage for research?
A3: The adipotide ftpp dosage in primate studies is 0.43 mg/kg subcutaneously daily for 28 days. The adipotide dosage chart from this research provides a reference for establishing adipotide ftpp dosage in other models.

Q4: How does Adipotide work?
A4: Adipotide binds to ANXA2 and prohibitin receptors on blood vessels supplying white adipose tissue, inducing apoptosis in endothelial cells and cutting off blood supply to fat cells.

Q5: Is Adipotide a peptide that kills fat cells?
A5: Yes, Adipotide is often described as a peptide that kills fat cells, but it works indirectly by inducing apoptosis in the vasculature that supplies fat cells, leading to their death.

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A7: In primate studies, Adipotide treatment was generally well tolerated, but dose-dependent renal tubular changes were observed. No human clinical data have been published as of 2026. Researchers should handle Adipotide with appropriate precautions.

Q8: What is the Adipotide FTPP 10mg purity?
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