Buy MOTS-c Peptide Online | The Mitochondrial Peptide for Metabolic Research
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Welcome to Planex Supplies, your trusted source for premium research peptides. If you are looking for mots c peptide for sale online, you have arrived at the right destination. Our MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a synthetic, high-purity 16-amino acid peptide (sequence: MRWQEMGYIFYPRKLR) that is identical to the endogenous human form. This mots c peptide for sale online has a molecular formula of C10H152N280O22S2 and a molecular mass of 2174.59 Daltons.
When you purchase mots c peptide for sale online from us, you receive lyophilized powder in sterile vials, verified by third-party laboratories to ensure exceptional purity and potency. Researchers seeking mots c peptide for sale online appreciate our transparent documentation, including batch-specific certificates of analysis. Browse our shop to explore our mots c peptide for sale online inventory. For related research compounds, visit our buy peptide online category. Our mots c peptide for sale online is intended for laboratory research use only, not for human consumption.
What is MOTS-c Peptide?
MOTS-c is a mitochondrial-derived peptide (MDP) encoded within the 12S ribosomal RNA region of mitochondrial DNA. Unlike most peptides that originate from nuclear genes, MOTS-c is produced directly by the mitochondrial genome, making it unique among known signaling molecules. This mots c peptide acts as a metabolic regulator, modulating the AMPK/PGC-1α pathway and enhancing insulin sensitivity.
Research has shown that MOTS-c inhibits the folate cycle and de novo purine synthesis, elevating AICAR levels to activate AMPK, which regulates the Nrf2/Keap1 antioxidant pathway and suppresses the NF-κB inflammatory pathway. When you purchase mots c peptide for sale online from Planex Supplies, you are accessing a cutting-edge research tool for investigating metabolic regulation, exercise mimetics, insulin sensitivity, and the molecular mechanisms of aging.
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- Product Name: MOTS-c
- Synonyms: 12S rRNA-c, MT-RNR1, Mitochondrial-Derived Peptide
- Amino Acid Sequence: Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg
- Molecular Formula: \(\text{C}_{101}\text{H}_{152}\text{N}_{28}\text{O}_{22}\text{S}_{2}\)
- Molecular Weight: 2174.64 g/mol
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- Significantly increases the prevalence of active brown adipose tissue.
- Suppresses the accumulation of visceral white adipose tissue.
- Translocates directly to the cell nucleus to halt lipid accumulation pathways.
Mots c Peptide Benefits
The mots c peptides benefits are wide-ranging and well-supported by scientific research. When you acquire mots c peptide for sale online, you are obtaining a compound with documented potential in multiple areas of research.
Metabolic Regulation and Insulin Sensitivity
One of the most significant mots c peptides benefits is its role in regulating glucose metabolism and improving insulin sensitivity. MOTS-c has been shown to enhance glucose uptake in cells and improve insulin sensitivity, particularly in muscle tissue. In vivo studies have demonstrated that MOTS-c significantly enhanced insulin-stimulated glucose clearance and improved insulin sensitivity in skeletal muscle. In a study using a rat type 2 diabetes model, MOTS-c (0.5 mg/kg; i.p.; once daily; 8 weeks) significantly decreased fasting blood glucose by 35%, HOMA-IR by 40%, and plasma triglycerides and total cholesterol by 25-30% compared to diabetic controls.
Anti-Inflammatory and Neuroprotective Effects
Additional mots c peptides benefits include anti-inflammatory and neuroprotective properties. MOTS-c has been shown to reduce inflammation associated with obesity and insulin resistance by modulating IL-6 and TNF-α. In a traumatic brain injury model, MOTS-c (50 mg/kg; i.p.; once daily; 21 days) reduced neurological severity scores by 45% and improved motor performance by 50% compared to injured controls. The peptide also suppresses the HMGB1/TLR4/NF-κB inflammatory pathway in brain tissue.
Muscle Health and Exercise Mimetic Effects
MOTS-c has been studied for its potential to support muscle function and mimic some effects of exercise. Research suggests MOTS-c helps maintain muscle strength and integrity during aging and protects against age-related skeletal muscle decline. It is considered an “exercise mimetic” because it can improve glucose uptake in skeletal muscle and enhance insulin sensitivity without requiring insulin. As MOTS-c is a major exercise-induced myokine with the highest expression in skeletal muscle, it acts as a regulator of cellular energy metabolism, promoting energy production, fatty acid oxidation, and mitochondrial function.
Anti-Aging and Longevity Research
MOTS-c has become a subject of interest in longevity and aging studies. The peptide may influence pathways associated with age-related metabolic decline and cellular health. Levels of MOTS-c decline with age – in humans, middle-aged individuals have lower MOTS-c levels than younger people, and elderly individuals show a 21% decrease. This decline correlates with increased risk of obesity, diabetes, and cardiovascular disease.
Mots c Dosage
Understanding mots c dosage is crucial for effective research. The mots c dosage can vary depending on the research model and administration route.
In Vivo Dosage
In rodent studies, mots c dosage has been tested at various levels:
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5 mg/kg/day (i.p.; 7 days): Significantly enhanced insulin-stimulated glucose clearance and improved insulin sensitivity in skeletal muscle
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25-50 mg/kg (i.p.; once daily; 21 days): Reduced neurological deficits in a traumatic brain injury model
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50 mg/kg (i.p.; single dose): Reduced paw licking time and inhibited spinal inflammatory markers in a formalin inflammation model
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0.5 mg/kg (i.p.; once daily; 8 weeks): Reduced fasting blood glucose and improved myocardial ultrastructural damage in a type 2 diabetes model
In Vitro Dosage
In cell culture studies, mots c dosage typically ranges from 0-100 μM, with 10 μM being a common concentration for studying AMPK activation.
Research Dosage Protocol
A common research vial size for MOTS-c is 10 mg, allowing laboratories to measure and prepare specific concentrations depending on experimental requirements. The lyophilized peptide is typically dissolved in a sterile solvent such as bacteriostatic water to achieve the desired concentration. Researchers should determine their own concentrations and dosing schedules based on the design of their experiments. When you purchase mots c peptide for sale online, you receive a product with detailed documentation to support your research.
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Understanding mots c peptide side effects is critical for responsible research. When you acquire mots c peptide for sale online, you should be aware of the potential side effects, although the mots c peptide side effects profile is generally favorable at standard research doses.
Reported Side Effects
Documented mots c peptide side effects in studies have been minimal in controlled settings. Potential mots c peptide side effects may include gastrointestinal upset (nausea or mild diarrhea), shifts in appetite or weight from altered metabolism, insulin sensitivity changes that might lead to hypoglycemia or glucose dysregulation, local injection site reactions when administered parenterally, and potential impacts on lipid profiles and liver enzymes. Human safety data for long-term MOTS-c use are limited, as the majority of evidence is animal-based or comes from small human trials with metabolic rather than reproductive endpoints.
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Q2: What is MOTS-c peptide?
A2: MOTS-c is a 16-amino acid mitochondrial-derived peptide (sequence: MRWQEMGYIFYPRKLR) encoded within the 12S ribosomal RNA region of mitochondrial DNA. This mots c peptide regulates metabolism through the AMPK/PGC-1α pathway.
Q3: What are the mots c peptides benefits in research?
A3: Mots c peptides benefits include enhancing insulin sensitivity, reducing inflammation, providing neuroprotection, and supporting muscle health. MOTS-c has been shown to decrease fasting blood glucose by 35% in a type 2 diabetes model.
Q4: What is the mots c peptide dosage for research?
A4: Mots c dosage in animal studies typically ranges from 0.5-50 mg/kg depending on the model and route. In vitro studies use 0-100 μM concentrations. A common mots c dosage for metabolic research is 5 mg/kg/day.
Q5: Are there mots c peptide side effects?
A5: Documented mots c peptide side effects in research are minimal. Potential mots c peptide side effects include gastrointestinal upset and local injection site reactions. Human safety data for long-term use are limited .
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