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PE-22-28: The Next-Generation Neuropeptide for Mood, Memory & Neuroplasticity

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Welcome to Planex Supplies, your trusted source for cutting-edge research peptides. If you are looking to Buy PE-22-28, you have arrived at the right destination. Our PE-22-28 is a high-purity, synthetic neuropeptide available in an 8mg lyophilized format, verified by third-party laboratories to ensure exceptional quality and potency. When you Buy PE-22-28 from us, you are investing in a compound with remarkable potential for research into mood regulation, cognitive enhancement, and neuroplasticity.

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PE-22-28 is a synthetic seven-amino-acid peptide (sequence GVSWGLR) derived from a larger naturally occurring peptide called spadin, itself processed from sortilin. This compact peptide, with a molecular weight of approximately 774 Da and purity exceeding 95%, was developed through research at the Institut de Pharmacologie Moléculaire et Cellulaire (IPMC) in France. When you Buy PE-22-28, you are acquiring a refined, more selective, and metabolically stable fragment derived from that pioneering research. PE-22-28 acts as a highly potent inhibitor of the TREK-1 potassium channel, with an IC₅₀ value of 0.12 nM. TREK-1 is a two-pore domain potassium channel that regulates neuronal excitability and neurotransmitter release in the brain.

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The mechanism of PE-22-28 is what makes it so compelling for researchers. PE-22-28 exerts its effects by binding to and inhibiting the TREK-1 potassium channel. TREK-1 is expressed in the raphe nuclei (the brain’s primary source of serotonergic neurons), the limbic system, and the prefrontal cortex — regions directly governing mood and emotional processing. When you Buy PE-22-28, you are acquiring a compound that modulates neuronal excitability and supports potassium flow across membranes. By attenuating TREK-1 activity, PE-22-28 supports neuronal firing and plasticity in key circuits, such as the hippocampus and prefrontal cortex.

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PE-22-28 Scientific Overview
PE-22-28 is a synthetic peptide that has gained attention in neurobiology and pharmacology research. It is a truncated analog of Spadin, a peptide derived from the propeptide of sortilin. While Spadin is a long-chain peptide, PE-22-28 consists of only seven amino acids, a modification intended to improve its chemical stability and receptor affinity during experimental studies.
Technical Specifications
For laboratory identification and chemical analysis, the properties of PE-22-28 are categorized as follows:
    • Amino Acid Sequence: GVSWGLR (Glycine-Valine-Serine-Tryptophan-Glycine-Leucine-Arginine)
    • Molecular Formula: C35H55N11O9
    • Molecular Weight: 773.89 g/mol
    • Functional Classification: TREK-1 Channel Antagonist

Research Mechanisms and Biological Context
1. TREK-1 Channel Interaction
The primary focus of PE-22-28 research involves its interaction with the TREK-1 (TWIK-related potassium channel-1) receptor. TREK-1 is a member of the two-pore domain potassium (K2P) channel family. These channels play a fundamental role in maintaining the resting membrane potential and regulating the excitability of neurons. TREK-1 is expressed throughout the central nervous system, with high concentrations found in regions associated with mood and cognition, such as the hippocampus and prefrontal cortex.
2. Neurogenic Potential
In animal models, the inhibition of TREK-1 channels has been associated with physiological changes in brain chemistry. Specifically, studies have investigated how blocking these channels might influence neurogenesis—the process by which new neurons are formed. Research suggests that Spadin and its analogs, like PE-22-28, may promote the release of brain-derived neurotrophic factor (BDNF), which is essential for the survival and growth of neurons in the hippocampus.
3. Pharmacological Comparison to Spadin
A significant area of interest is the comparison between full-length Spadin and the synthetic PE-22-28 variant. Natural peptides often have a short half-life and are quickly degraded by enzymes in biological systems. By reducing the sequence to its active core, researchers aim to observe if the shorter analog maintains the same functional antagonism of the TREK-1 channel while offering improved resistance to metabolic degradation.
Safety and Regulatory Status
PE-22-28 is a research chemical utilized in preclinical laboratory settings, primarily in vitro or in animal models. It has not been approved for clinical use in humans. Due to the limited nature of existing data, its long-term physiological effects and safety profile remain subjects of ongoing academic investigation. The study of TREK-1 antagonists represents a specialized field of neuroscience aimed at understanding the fundamental mechanics of neuronal signaling and hippocampal plasticity.

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