PE-22-28: The Next-Generation Neuropeptide for Mood, Memory & Neuroplasticity
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PE-22-28 is a synthetic seven-amino-acid peptide (sequence GVSWGLR) derived from a larger naturally occurring peptide called spadin, itself processed from sortilin. This compact peptide, with a molecular weight of approximately 774 Da and purity exceeding 95%, was developed through research at the Institut de Pharmacologie Moléculaire et Cellulaire (IPMC) in France. When you Buy PE-22-28, you are acquiring a refined, more selective, and metabolically stable fragment derived from that pioneering research. PE-22-28 acts as a highly potent inhibitor of the TREK-1 potassium channel, with an IC₅₀ value of 0.12 nM. TREK-1 is a two-pore domain potassium channel that regulates neuronal excitability and neurotransmitter release in the brain.
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- Amino Acid Sequence: GVSWGLR (Glycine-Valine-Serine-Tryptophan-Glycine-Leucine-Arginine)
- Molecular Formula: C35H55N11O9
- Molecular Weight: 773.89 g/mol
- Functional Classification: TREK-1 Channel Antagonist
The primary focus of PE-22-28 research involves its interaction with the TREK-1 (TWIK-related potassium channel-1) receptor. TREK-1 is a member of the two-pore domain potassium (K2P) channel family. These channels play a fundamental role in maintaining the resting membrane potential and regulating the excitability of neurons. TREK-1 is expressed throughout the central nervous system, with high concentrations found in regions associated with mood and cognition, such as the hippocampus and prefrontal cortex.
In animal models, the inhibition of TREK-1 channels has been associated with physiological changes in brain chemistry. Specifically, studies have investigated how blocking these channels might influence neurogenesis—the process by which new neurons are formed. Research suggests that Spadin and its analogs, like PE-22-28, may promote the release of brain-derived neurotrophic factor (BDNF), which is essential for the survival and growth of neurons in the hippocampus.
A significant area of interest is the comparison between full-length Spadin and the synthetic PE-22-28 variant. Natural peptides often have a short half-life and are quickly degraded by enzymes in biological systems. By reducing the sequence to its active core, researchers aim to observe if the shorter analog maintains the same functional antagonism of the TREK-1 channel while offering improved resistance to metabolic degradation.
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